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Trial-cohort obese (BMI 3040) : the calculators usual entry point is 0.5 mg, then the full bridge ladder toward 4/5 mg, with 69 mg available for higher-adiposity, MASLD, T2D/high-HbA1c, or plateau profiles

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Since the thyroid gland mainly produces T4, thyroid supplementation seems straightforward: simply provide T4 and the system should work